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| 1-phosphatidyl-1D-myo-inositol 4-phosphate ： ウィキペディア英語版 |
Phosphatidylinositol 4-phosphate
Phosphatidylinositol 4-phosphate (PtdIns4''P'', PI-4-P or simply PI4P) is a precursor of Phosphatidylinositol (4,5)-bisphosphate. PtdIns4''P'' is prevalent in the membrane of the Golgi apparatus.
In the Golgi apparatus, PtdIns4''P'' binds to the GTP-binding protein ARF and to effector proteins, including four-phosphate-adaptor protein 1 and 2 (FAPP1 and FAPP2).〔Godi A et al., FAPPs control Golgi-to-cell-surface membrane traffic by binding to ARF and PtdIns(4)P. Nat Cell Biol. 2004 May;6(5):393-404.〕 This three molecule complex recruits proteins that need to be carried to the cell membrane.〔Choudhury RR, Hyvola N, Lowe M. Phosphoinositides and membrane traffic at the trans-Golgi network. Biochem Soc Symp. 2005;(72):31-8.〕
There is now evidence that PI-4-P is capable of deforming lipid systems into tightly curved assemblies, this is consistent with similar behaviour observed in phosphatidylinositol.
==References==
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抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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